Endocrine Abstracts

Aims: We assessed periodontal status in patients with type 1 diabetes and healthy individuals in relation to their glycemic control, smoking, and inflammatory biomarkers.Methods: Periodontal status was examined in 107 patients with type 1 diabetes and 40 controls, using oral hygiene index (OHI), community periodontal index (CPI) and teeth number. CPI values of 0–2 and 3–4 were classified as non-periodontitis and periodontitis respectively. Bloo...

Before the introduction of mandatory salt iodination in 1997 the North-Eastern Region of Poland was known to be a moderate iodine deficiency area. It was also exposed to ionizing radiation after the Chernobyl accident in 1986. The aim of the present study was to evaluate the descriptive epidemiological features of incident thyroid cancers diagnosed among the residents of this area between 1996 and 2007. The Regional Cancer Surveillance Program was used to collect data on 834 n...

Gestational diabetes mellitus (GDM) identifies a population of women at high risk of subsequent type 2 diabetes mellitus, representing an early stage in the natural history of the disease. Systemic inflammation is associated with the development of type 2 diabetes but the data concerning pro- and anti-inflammatory cytokines in patients with GDM are limited. The aim of our study was to investigate serum concentrations of interleukin-8 (IL-8), IL-18 and IL-10 in pregnant women w...

Background: Interleukin-15 and -6 play a role in an inflammation, autoimmune, infectious and cancerous processes. Their increased concentrations were observed in psoriasis, asthma, multiple sclerosis and type 2 diabetes. However, the role of IL-15 and IL-6 in autoimmune diabetes (AD) pathogenesis is still unknown.Aim: The aim of our study was to assay circulating IL-15 and IL-6 levels in newly diagnosed AD patients, their I° relatives and healthy co...

Purpose: Recent reports strongly suggest that at least some cases of Hashimoto’s thyroiditis (HT) may be closely associated with IgG4-related disease. In the present study we aimed to find out, whether the measurement of serum IgG4 allows for an identification of distinct types of HT, with different clinical, sonographic and serologic characteristics.Methods: The group studied consisted of 53 patients with HT and 28 healthy individuals. All the part...

Background and aims: In patients with type 2 diabetes, elevated tumor necrosis factor α (TNFα), C-reactive protein (CRP), chemerin, fetuin-A, have been reported. However, it is not entirely clear whether these alterations in adipokine serum concentrations are already present in prediabetic states and in type 1 diabetes. The aim of the study was to investigate whether adipokine profiles (chemerin, fetuin-A, TNFα) and inflammatory markers (CRP) are associated with...

Aim: It is well known that T1D is associated with other autoimmune diseases. The aim of this study was to compare the prevalence of various auto-antibodies in first-degree relatives of patients with T1D and healthy individuals with negative family history of diabetes.Material and methods: The group studied consisted of 90 relatives and 60 healthy individuals. Serum concentrations of antibodies to anti-21-hydroxylase (21-OH-Abs), anti-gastric parietal cel...

Introduction: Thyroid hormones deficiency in the course of subclinical and overt hypothyroidism is frequently related to the increased body mass, reduced thermogenesis and metabolic rate however the pathogenesis of improper body mass in Hashimoto thyroiditis (HT) patients is still an open question. Therefore, in the present study we compared body mass and body composition between the patients with Hashimoto thyroiditis who were in clinical and hormonal euthyreosis and healthy ...

A higher incidence of nodular goitre and less differentiated types of thyroid carcinoma have been observed in iodine deficient regions. North-Eastern Poland was an area with a moderate deficiency of iodine until the introduction of the mandatory salt iodination in 1997 (30±10 mg KJ/kg NaCl). The aim of our study was to compare the incidence of goitre, thyroid carcinoma and urine excretion of iodine in the inhabitants of the North-Eastern Region of Poland in 1997 and 2005....

Introduction: Resistin is a cysteine–rich adipokine that was originally described as a molecular link between obesity and insulin resistance. Our previous study showed higher serum resistin levels in patients with gestational diabetes mellitus (GDM) in comparison with healthy pregnant women however conflicting results have been reported by other authors. Therefore in the present study we investigated whether there were significant differences in resistin mRNA expression i...